In Lewy body dementia, which medication class is commonly used to support cognition?

• A. Beta-blockers
• B. Antibiotics
• C. Cholinesterase inhibitors
• D. Benzodiazepines

Answer: (C)

Cholinesterase inhibitors are used because Lewy body dementia involves a loss of cholinergic neurons, leading to problems with attention and memory. By slowing the breakdown of acetylcholine, these medications boost acetylcholine levels where they’re needed, helping to improve cognitive function and attention in this condition. Rivastigmine has strong supporting evidence for Lewy body dementia and is specifically approved for it; donepezil and galantamine are also used for cognition in this disorder. Other drug classes don’t target this cholinergic deficit: beta-blockers treat heart conditions, antibiotics fight infections, and benzodiazepines can worsen confusion and sedation in dementia.